Melatonin in the skin: synthesis, metabolism and functionsAndrzej Slominski1, , Desmond J. Tobin2, Michal A. Zmijewski1, Jacobo Wortsman3 and Ralf Paus4
1Department of Pathology and Laboratory Medicine, University of Tennessee HSC, Memphis, TN, USA
2Medical Biosciences Research, School of Life Sciences, University of Bradford, West Yorkshire, UK
3Department of Medicine, Southern Illinois University, Springfield, IL, USA
4Department of Dermatology, University of Luebeck, Luebeck, Germany
melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin. melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cells.