Reducir la frecuencia de los ataques de cefalea con la melatonina

Estudio piloto para el tratamiento de la cefalea con la melatonina.  El objetivo del estudio, llevado a cabo por la Universidad de Atenas, fue evaluar la eficacia potencial de la melatonina para la prevención de cefalea primaria. Los resultados obtenidos por la ingesta de 4 mg de melatonina, 30 minutos antes de ir a la cama durante seis meses, han sido significativos en cuanto a una reducción estadísticamente significativa en la frecuencia de cefalea en los pacientes involucrados en el estudio.

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study.

Funct Neurol. 2016 Jan-Mar;31(1):33-7
Authors: Bougea A, Spantideas N, Lyras V, Avramidis T, Thomaidis T

There is growing evidence that headaches are connected to melatonin secretion. Our aim was to assess the potential effectiveness of melatonin for primary headache prevention. Forty-nine patients (37 with migraine and 12 with chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime for six months. Forty-one (83.6%) of the 49 patients completed the study, while eight dropped out for personal reasons. A statistically significant reduction in headache frequency was found between baseline and final follow-up after six months of treatment (p=0.033 for TTH patients and p<0.001 for migraineurs). The Headache Impact Test score was significantly reduced in both groups of headache patients (p=0.002 and p<0.001, respectively). At baseline, melatonin levels, measured both during a headache attack and a pain-free period, did not differ between patients with TTH and migraineurs (p=0.539 and p=0.693, respectively), and no statistically significant differences in Hamilton Depression Rating Scale scores were found between the two groups. Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement, in both groups.

PMID: 27027892 [PubMed - in process]

Key Melatonin